Sir Keir Starmer has urged anyone with information on the Jeffrey Epstein case to come forward after Andrew Mountbatten Windsor missed the deadline to appear in front of US Congress.
US legislators have criticised Andrew for what they describe as "silence" amid their probe into Epstein after he failed to respond to their request for an interview.
When asked about Andrew missing the deadline and whether the former prince should help the case in any way he can, Sir Keir said on his way to the G20 summit in South Africa: "I don't comment on this particular case."
He added that "a general principle I've held for a very long time is that anybody who has got relevant information in relation to these kind of cases should give that evidence to those that need it".
Andrew is not legally obliged to talk to Congress and has always vigorously denied any wrongdoing.
It comes as Marjorie Taylor Greene, a loyal supporter-turned-critic of US President Donald Trump, said on Friday she is resigning from Congress in January.
Ms Greene's resignation followed a public falling-out with Mr Trump in recent months, as the congresswoman criticised him for his stance on files related to Epstein, as well as on foreign policy and healthcare.
Members of the House Oversight Committee had requested a "transcribed interview" with Andrew in connection with his "long-standing friendship" with Epstein, the paedophile financier who took his own life in a New York prison in 2019 while awaiting trial on sex trafficking and conspiracy charges.
But after saying they had not heard back, Democrats Robert Garcia and Suhas Subramanyam accused Andrew of hiding.
Their statement read: "Andrew Mountbatten Windsor's silence in the face of the Oversight Democrat's demand for testimony speaks volumes.
"The documents we've reviewed, along with public records and Virginia Roberts Giuffre's testimony, raise serious questions he must answer, yet he continues to hide.
"Our work will move forward with or without him, and we will hold anyone who was involved in these crimes accountable, no matter their wealth, status, or political party. We will get justice for the survivors."
It follows Andrew being stripped of his prince and Duke of York titles earlier this month.
He had previously agreed to stop using his titles, but had expected to remain a prince and retain his dukedom, ahead of the publication of the memoirs of the late Ms Giuffre, who had accused him of sexually assaulting her when she was a teenager - an accusation he denies.
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